Why are malformations of amphibians insufficient evidence for chemical toxicity?

Malformations may come from parasites and other influences that are not necessarily related to pollutants. Also a one low concentration effect of a compound like atrazine does not mean that malformations found in the wild are due to that agent.

Exam 1: Biological Research in Toxicology

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What toxicological information does the whole organism give toxicologists as exemplified by the injection of ¹⁴C -labeled esophageal carcinogen N-nitrosomethylbenzylamine?

Correct Answer
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The distribution and activation by biotransformation was highest in the target organ which cannot be determined by exposing just one cell fraction from one tissue.

How is toxicogenomics a form of cellular toxicology?

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Toxicogenomics involves changes in DNA structure, expression and translation into protein (via mRNA transcription and tRNA/ribosomal protein synthesis) that are cellular functions of the nucleus (for eukaryotic organisms) and the cytoplasm/endoplasmic reticulum. A cancer cell may indeed by one aberrant cell whose genomics has been sufficiently altered to be a grave danger to the entire organism but started as a focus.

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Exam 1: Biological Research in Toxicology

What toxicological information does the whole organism give toxicologists as exemplified by the injection of 14C -labeled esophageal carcinogen N-nitrosomethylbenzylamine?

Correct AnswerverifiedThe distribution and activation by biotransformation was highest in the target organ which cannot be determined by exposing just one cell fraction from one tissue.

How is toxicogenomics a form of cellular toxicology?

Why are malformations of amphibians insufficient evidence for chemical toxicity?

Correct AnswerverifiedMalformations may come from parasites and other influences that are not necessarily related to pollutants. Also a one low concentration effect of a compound like atrazine does not mean that malformations found in the wild are due to that agent.

What toxicological information does the whole organism give toxicologists as exemplified by the injection of ¹⁴C -labeled esophageal carcinogen N-nitrosomethylbenzylamine?

Correct Answer
verified
The distribution and activation by biotransformation was highest in the target organ which cannot be determined by exposing just one cell fraction from one tissue.

Correct Answer
verified
Malformations may come from parasites and other influences that are not necessarily related to pollutants. Also a one low concentration effect of a compound like atrazine does not mean that malformations found in the wild are due to that agent.